The reaction between phenacyl bromide and 2-mercaptobenzimidazole has been studied in 12 different protic and aprotic solvents. The kinetic study shows that the reaction is second-order with first-order dependence each on (phenacyl bromide) and (2-mercaptobenzimidazole). Analysis of rate data shows that there is no direct correlation between the rate constant and dielectric constant of the solvent. Correlation of rate data with different solvent parameters like hydrogen bond acceptor basicity, polarizability and solvent electrophilicity, using linear multiple regression analysis shows that the reaction is influenced by these properties of the solvent. From the regression coefficients, information on the mode of solvation of the reactants and the transition state is obtained. The reaction has also been studied at different temperatures and the thermodynamic parameters Δ H #, Δ S # and Δ G # are evaluated.
B. Kavitha, P. Manikyamba
Journal of Sulfur Chemistry