Finding
The incidence of basal-like and penta-negative tumors is lower than that in other countries.
Paper
Immunohistochemical characterization of the molecular subtypes of invasive breast carcinoma in a series of Egyptian female patients with clinicopathologic correlation
Citations: 0
Full textAbstract
Background Breast cancer is a heterogeneous disease, with molecular differences existing among histologically identical tumors. Histologic classifications cannot fully capture the clinical course, whereas molecular analysis may provide information that might improve the prognostic prediction. Aim The aim of this study was to define the prevalence of the molecular subtypes using a surrogate immunohistochemical panel and to analyze the clinicopathological features of these molecular subtypes. Patients and methods Hundred cases of invasive breast carcinomas were immunostained for ER, PR, HER2, Ki-67, CK5/6 and EGFR to determine the molecular subtype. Results Luminal B was the most common molecular type (63%), followed by the triple negative (15%), luminal A (14%), and HER2 enriched (8%). Tumor grade varied significantly between the molecular subtypes. HER2-positive subtypes showed higher tumor stage and grade, with significance reached for stage only. Lower tumor grade and stage prevailed among luminal tumors, with significance for grade only. Associated in-situ carcinoma was significantly higher among nonluminal tumors. Nodal metastasis did not vary significantly between the molecular subtypes. Conclusion The luminal B HER2-negative subtype is the most common molecular subtype among female breast carcinomas at our center. The incidence of basal-like and penta-negative tumors is lower than that in other countries. The luminal subtypes in contrast to HER2-positive molecular subtypes are more likely to present as low-grade and stage tumors.
Authors
S. El-Gendi, Mai Ahmed, L. Younis
Journal
Egyptian Journal of Pathology