In this study the effect of chronical exposal of workers to toluen and xylen in working conditions, and the effect both on lipid status and TAS level in plasma was followed. Hippuric acid in the urine was determined before and after work, as the exposition measure. Hippuric acid was increased in urine excretion after work, within the group of the exposed, which confirms the exposition to xenobiotics. Concentration of triglycerides, overall and LDL cholesterol of the plasma were substantially increased (p 0.001). Increased production of free radicals support the increased production of antioxidants, that results with TAS lower findings within the exposed group (p<0.001). Free radicals change the structure of the cell membrane, biomacromolecular structure and consequently the physiological function. Defense from the modification of lipoprotein and cell structure, and modification of proteins is defined by antioxidative status in blood.
V. Knežević, D. Joksovic, O. Knezević
Jugoslovenska Medicinska Biohemija-yugoslav Medical Biochemistry