Finding
Phosphorylation of both sites is required for inhibition of protein synthesis.
Paper
Two phosphorylation sites on eIF‐2α
Abstract
Protein synthesis in mammalian cells can be regulated through phosphorylation/dephosphorylation of the α subunit of initiation factor 2, eIF‐2. Two specific kinases have been identified that apparently phosphorylate the same site(s). Controversy exists as to whether serine‐48 is a phosphorylation site in addition to serine‐51. A recent publication is discussed that, in this author's view, answers the question of the phosphorylation sites. It is suggested that phosphorylation procedes sequentially with serine‐51 being the first and serine‐48 the second phosphorylation site. Phosphorylation of both sites is required for inhibition of protein synthesis.
Authors
G. Kramer
Journal
FEBS Letters
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