Finding
Intracerebral pressure, sagittal sinus pressure, and cerebral flux increased in both groups during cross-clamping of the descending thoracic aorta.
Paper
Effect of sodium nitroprusside on cerebral haemodynamics during cross-clamping of the descending thoracic aorta in pigs.
Citations: 4
Full textAbstract
OBJECTIVE To assess the effect of sodium nitroprusside on cerebral haemodynamics during cross-clamping of the descending thoracic aorta in pigs. DESIGN Non-randomised controlled animal study. SETTING University hospital, Norway. MATERIAL 17 Pigs. INTERVENTIONS Cross-clamping of the descending thoracic aorta for 30 minutes. In 8 pigs sodium nitroprusside was given to prevent proximal hypertension (sodium nitroprusside group); 9 pigs were given no sodium nitroprusside (control group). MAIN OUTCOME MEASURES Intracerebral pressure, sagittal sinus pressure, cerebral flux, and internal carotid artery blood flow. RESULTS Intracerebral pressure, sagittal sinus pressure, and cerebral flux increased in both groups during cross-clamping of the descending thoracic aorta. There were no differences between the groups in these variables despite significantly lower mean proximal aortic pressure in the sodium nitroprusside group. CONCLUSIONS Sodium nitroprusside did not affect intracerebral pressure, sagittal sinus pressure, or cerebral flux during cross-clamping of the descending thoracic aorta. Increased cerebral blood flow rather than venous congestion is the most likely cause of increased intracranial pressure during cross-clamping of the descending thoracic aorta.
Authors
T. Strømholm, P. Aadahl, O. Saether
Journal
The European journal of surgery = Acta chirurgica