Article history Cytogenetic damage associated with prallethrin based mosquito repellent use was analyzed by micronuclei (MN) and other nuclear abnormalities (NA) in South Indian human volunteers. The mean MN frequency of exposed subjects showed a significant difference when compared with controls (p<0.05). The presence of other NA such as binucleated cells (BNC), karyorrhexis (KRC) and karyolysis (KLC) were found to be notably higher in exposed individuals (p<0.05). These results show that chronic exposure to prallethrin increases a slight DNA damage. Though the present investigation involving a limited number of human subjects indicates the onset of both protective changes as well as derangement in metabolism, a detailed and rigorous study is greatly warranted to arrive at a definite conclusion about any toxic effects of prallethrin based mosquito repellents.
Karthikeyan S. Kripa, S. Sudha, S. Singaravelu
Indo American Journal of Pharmaceutical Research