This concept is strengthened by recent evidence showing that specific conformational features of the secondary structure of the N-terminus of the NS3 protein, characteristics of certain strains of HCV type 1b, are associated with an increased risk of HCC,3 thus providing a plausible pathogenetic basis for our findings.

Hepatology

surveillance intervals appear to be adequate for both patient groups, as recommended by international guidelines. Still, clinicians should be aware of the potentially higher oncogenic risk of genotype 1b in addition to other recognized risk factors and, to this end, it would be reasonable to recommend a more careful follow-up of these patients. This concept is strengthened by recent evidence showing that specific conformational features of the secondary structure of the N-terminus of the NS3 protein, characteristics of certain strains of HCV type 1b, are associated with an increased risk of HCC,3 thus providing a plausible pathogenetic basis for our findings.

Racial disparities in the management of hospitalized patients with cirrhosis and portal hypertension