Objective: In the present study, the importance of the pulse pressure amplitude as a marker of the risk of myocardial infarction (MI) is discussed. Methods: The 88 survivors of myocardial infarction were evaluated and a group of 106 healthy people is used as controls. The biomarkers: total cholesterol, HDL – cholesterol, serum triglycerides and LDL – cholesterol is measured with biochemical analyzer “Cobas Integra 400 (Roche)”. ANOVA analysis is performed and multivariate analyses are conducted with multiple logistic regression methods. Results: The mean systolic blood pressure is significantly higher in MI participants. The relation between odds and pulse pressure amplitude, according to obtained models, indicates increasing of odds when the value of pulse pressure amplitude is greater. The p-value for overall model fit statistic is from 8.2173×10-5 to 0.0026 for different models and it is evidence that pulse pressure amplitude is a marker for MI risk. In the simplest model only pulse pressure amplitude is included as predictor variable whereas pulse pressure amplitude, sex and smoking are included in the most complex model. Results show that for a given pulse pressure amplitude odds of MI are significantly greater for men than for women. Expected increase of odds for the pulse pressure amplitude increase with 0.1 is obtained. Conclusions: The studies prove that pulse pressure amplitude is a marker of myocardial infarction risk. When the pulse pressure amplitude is used for risk level evaluation at least sex should be taken into account. Obtained results show that increased pulse pressure amplitude is greater risk for men than for women.
G. Atanasova, M. Marinov
Journal of Clinical and Experimental Cardiology