Health Benefits of Citrulline

This post was written with Consensus AI Academic Search Engine – please read our Disclaimer at the end of this article. Citrulline, a non-essential amino acid, has gained attention for its potential health benefits, particularly in enhancing physical performance, improving body composition, and supporting metabolic health. This article explores the various health benefits of citrulline supplementation based on recent research findings.

Body Composition and Metabolic Health

Citrulline supplementation has been shown to positively affect body composition and metabolic health. In aged male rats, citrulline treatment resulted in increased lean body mass and reduced fat mass, along with a decrease in lipid oxidation susceptibility, suggesting its potential in mitigating age-related metabolic changes1. Similarly, in malnourished older patients, citrulline supplementation was associated with increased lean mass and decreased fat mass, particularly in women, indicating its role in improving body composition3.

Exercise Performance and Recovery

Citrulline is known to enhance exercise performance and recovery. Studies have demonstrated that citrulline supplementation improves oxygen uptake kinetics and exercise tolerance in humans, leading to better performance in high-intensity exercises2. Additionally, citrulline malate has been found to enhance anaerobic performance and reduce muscle soreness post-exercise, making it beneficial for athletes undergoing intensive training4. In cycling time trials, citrulline supplementation reduced completion time and improved subjective feelings of muscle fatigue6.

Cardiovascular and Endothelial Health

Citrulline’s role as a precursor to nitric oxide (NO) synthesis contributes to its cardiovascular benefits. It has been shown to improve endothelial function and reduce blood pressure, particularly in hypertensive postmenopausal women when combined with resistance training10. This vasodilatory effect can enhance blood flow and support cardiovascular health.

Insulin Sensitivity and Inflammation

Citrulline may also have implications for insulin sensitivity and inflammation. In type 2 diabetes patients, citrulline supplementation reduced fasting blood glucose and HbA1c levels, although it did not significantly improve insulin sensitivity or inflammation markers7. This suggests potential benefits in glucose metabolism, warranting further investigation.

Sarcopenia and Muscle Health

For older adults, citrulline supplementation, especially when combined with exercise, may help manage sarcopenia by improving muscle mass and strength. Studies indicate that citrulline can enhance muscle function and delay sarcopenia progression, making it a promising supplement for aging populations9.

Conclusion

Citrulline supplementation offers a range of health benefits, from improving body composition and exercise performance to supporting cardiovascular health and potentially aiding in glucose metabolism. Its role in enhancing nitric oxide production and muscle protein synthesis makes it a valuable supplement for both athletes and older adults. Further research is needed to fully understand its mechanisms and optimize its use in various health contexts.

Disclaimer

The content presented in this blog is generated by Consensus, an AI-powered academic search engine, and is based on publicly available scientific literature. While every effort is made to provide accurate, up-to-date, and well-researched information, the content is intended for informational and educational purposes only. It does not constitute medical advice, diagnosis, or treatment. Always consult a qualified healthcare professional before making any decisions regarding medical conditions, treatments, or medications. The AI system’s analysis may not cover all perspectives, emerging research, or individual cases, and it is not a substitute for professional expertise. Neither the blog publisher nor the developers of the AI-powered search engine are responsible for any actions taken based on the information provided in this content. Use of this information is at your own risk. Citations to the original scientific studies are included for reference, but these studies should be reviewed in full and interpreted with the guidance of a healthcare or research professional.

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