Nattokinase: Uses and Risks

This post was written with Consensus AI Academic Search Engine – please read our Disclaimer at the end of this article. Nattokinase, an enzyme derived from the traditional Japanese food natto, has gained attention for its potential health benefits, particularly in cardiovascular health. This article explores the uses of nattokinase, focusing on its effects on blood pressure, lipid levels, and cardiovascular health, as well as the associated risks.

Uses of Nattokinase

Blood Pressure Reduction

Nattokinase has been shown to have antihypertensive effects. In a North American clinical trial, nattokinase consumption was associated with a significant reduction in both systolic and diastolic blood pressure among hypertensive individuals, with more pronounced effects observed in males1. Another study confirmed these findings, demonstrating reductions in systolic and diastolic blood pressure in pre-hypertensive and stage 1 hypertensive subjects5. Animal studies also support these findings, showing that nattokinase can significantly reduce blood pressure in hypertensive rats7.

Lipid Level Improvement

Nattokinase has been studied for its potential to improve lipid profiles. A study combining nattokinase with red yeast rice showed significant reductions in triglycerides and total cholesterol, as well as an increase in high-density lipoprotein cholesterol in patients with stable coronary artery disease3. Additionally, nattokinase monascus supplements were found to ameliorate lipid levels, including total cholesterol and low-density cholesterol, without adverse events2.

Cardiovascular Health

Nattokinase is believed to have antithrombotic properties, which may contribute to cardiovascular health. A study on its effects on hemostatic factors found that nattokinase supplementation prolonged collagen-epinephrine closure time and activated partial thromboplastin time, suggesting a potential role in reducing thrombosis risk4. However, a long-term study on subclinical atherosclerosis progression found no significant effects of nattokinase supplementation on cardiovascular biomarkers6.

Risks and Safety

Nattokinase is generally considered safe, with studies reporting no significant adverse effects related to its consumption2 3. However, its long-term effects and interactions with other medications, particularly anticoagulants, require further investigation. The absence of significant adverse events in clinical trials suggests that nattokinase can be safely incorporated into dietary interventions for cardiovascular health, but caution is advised for individuals with bleeding disorders or those on blood-thinning medications.

Conclusion

Nattokinase shows promise in reducing blood pressure and improving lipid profiles, contributing to cardiovascular health. While it is generally safe, further research is needed to fully understand its long-term effects and interactions with other treatments. As with any supplement, individuals should consult healthcare professionals before starting nattokinase, especially if they have existing health conditions or are taking other medications.

Disclaimer

The content presented in this blog is generated by Consensus, an AI-powered academic search engine, and is based on publicly available scientific literature. While every effort is made to provide accurate, up-to-date, and well-researched information, the content is intended for informational and educational purposes only. It does not constitute medical advice, diagnosis, or treatment. Always consult a qualified healthcare professional before making any decisions regarding medical conditions, treatments, or medications. The AI system’s analysis may not cover all perspectives, emerging research, or individual cases, and it is not a substitute for professional expertise. Neither the blog publisher nor the developers of the AI-powered search engine are responsible for any actions taken based on the information provided in this content. Use of this information is at your own risk. Citations to the original scientific studies are included for reference, but these studies should be reviewed in full and interpreted with the guidance of a healthcare or research professional.

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