What Is a DHEA Test?

Understanding the DHEA Test

This post was written with Consensus AI Academic Search Engine – please read our Disclaimer at the end of this article. Dehydroepiandrosterone (DHEA) is a steroid hormone produced by the adrenal glands, which serves as a precursor to male and female sex hormones, including testosterone and estrogen. DHEA levels naturally decline with age, and this reduction has been associated with various age-related conditions1 2 6.

Purpose of the DHEA Test

The DHEA test is primarily used to measure the levels of DHEA in the blood. This test can help evaluate adrenal gland function and diagnose conditions related to abnormal hormone levels. It is often used in the context of assessing adrenal tumors, adrenal insufficiency, and certain types of congenital adrenal hyperplasia5 6.

Clinical Applications

1. Cognitive and Mood Assessment: Research has explored the potential of DHEA supplementation to improve cognitive function and mood, particularly in older adults. However, findings have been mixed, with some studies showing no significant benefits in cognitive performance or well-being from DHEA supplementation1 6.

2. Stress and Memory: DHEA has been studied for its effects on memory and stress response. Some studies suggest that DHEA may enhance attention and modulate memory, particularly under stress, although results are not consistently positive across all cognitive domains2 3.

3. Metabolic Effects: DHEA administration has been shown to affect body composition, such as reducing body fat and serum low-density lipoprotein levels, although it does not appear to alter insulin sensitivity significantly5.

Methodology of the DHEA Test

The DHEA test typically involves a blood sample, which is analyzed to determine the concentration of DHEA sulfate (DHEAS), the stable form of DHEA in the bloodstream. This test can be part of a broader hormonal panel to assess overall endocrine function6 8.

Implications of Test Results

• High DHEA Levels: Elevated DHEA levels may indicate adrenal hyperplasia, adrenal tumors, or polycystic ovary syndrome (PCOS) in women.
• Low DHEA Levels: Reduced levels can be associated with adrenal insufficiency, aging, and certain chronic illnesses5 6.

Conclusion

The DHEA test is a valuable tool in assessing adrenal function and diagnosing hormonal imbalances. While DHEA supplementation has been explored for various health benefits, including cognitive enhancement and mood improvement, the evidence remains inconclusive, highlighting the need for further research to fully understand its potential therapeutic roles.

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