What Is Collagen Type II (Native)? Other Names: Chicken Collagen Type II, Colágeno de Pollo, Collagen II

What is Collagen Type II (Native)?

This post was written with Consensus AI Academic Search Engine – please read our Disclaimer at the end of this article. Collagen Type II (Native), also known as undenatured type II collagen, is a protein primarily found in cartilage. It plays a crucial role in maintaining the structural integrity and function of cartilage, making it a significant focus in the treatment of joint-related conditions such as osteoarthritis and rheumatoid arthritis. Other names include: Chicken Collagen Type II, Chicken Type II Collagen, Colágeno de Pollo, Collagen II, Collagen Type II, Collagène de Poulet, Collagène de Type II, Collagène de Type II de Cartilage de Poulet, Collagène de Type II Hydrolysé, Hydrolyzed Chicken Collagen Type II, Hydrolyzed Collagen Type II, Type II Collagen.

Clinical Applications of Collagen Type II (Native)

Osteoarthritis

Several studies have demonstrated the efficacy of Native Collagen Type II in managing osteoarthritis symptoms. For instance, a randomized controlled trial showed that patients with knee osteoarthritis who received Native Collagen Type II along with acetaminophen experienced significant improvements in joint pain, function, and quality of life compared to those who received only acetaminophen2. Another study confirmed that Native Collagen Type II significantly improved knee joint function and reduced pain in osteoarthritis patients over a 180-day period6.

Rheumatoid Arthritis

Native Collagen Type II has also shown promise in treating rheumatoid arthritis. A double-blind trial involving patients with severe rheumatoid arthritis found that oral administration of chicken type II collagen led to a decrease in the number of swollen and tender joints, with some patients even achieving complete remission7.

Benefits and Efficacy

The benefits of Native Collagen Type II extend beyond just pain relief. It has been shown to improve overall joint health, reduce inflammation, and enhance the quality of life for individuals suffering from joint disorders. For example, a study on ageing db/db mice demonstrated that Native Collagen Type II improved bone mineral density, reduced inflammatory cytokines, and decreased oxidative stress, thereby alleviating bone impairment1.

Safety and Tolerability

Native Collagen Type II is generally well-tolerated with minimal side effects. Clinical trials have reported no significant adverse events, making it a safe option for long-term use in managing joint health8.

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Collagen Type II (Native) Mechanism of Action

Native Collagen Type II works by modulating the immune response and reducing inflammation. It is believed to induce oral tolerance, a process where the immune system becomes less reactive to specific antigens, thereby reducing autoimmune attacks on joint cartilage. This mechanism is particularly beneficial in conditions like rheumatoid arthritis, where the immune system mistakenly targets joint tissues7.

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Adverse Effects of Collagen Type II (Native)

Rheumatoid Arthritis Treatment: In a study involving patients with severe, active rheumatoid arthritis, oral administration of chicken type II collagen for three months resulted in a decrease in the number of swollen and tender joints. Importantly, no side effects were reported in this study, suggesting a favorable safety profile for collagen type II in this context2.

Osteoarthritis Model: In a rat model of osteoarthritis, undenatured type II collagen (UC-II) was found to reduce inflammatory responses and articular cartilage damage. The study did not report any adverse effects, indicating that UC-II might be safe for use in managing osteoarthritis3.

Collagen-Induced Arthritis in Mice: Another study on collagen-induced arthritis in mice using a novel water-soluble undenatured type II collagen (NEXT-II) also did not report any adverse effects. The treatment was effective in reducing arthritis symptoms and modulating immune responses without noted side effects4.

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How has Collagen Type II (Native) Improved Patient Outcomes?

Pain Reduction

Visual Analogue Scale (VAS) Scores: Multiple studies reported significant reductions in pain scores for patients treated with native type II collagen compared to control groups. This includes reductions in pain at rest, during walking, and at night1 3 4 5.

WOMAC Pain Subscale: Improvements in the WOMAC pain subscale were noted, indicating reduced pain severity in daily activities2 5 6.

Improved Joint Function

WOMAC Function Scores: Patients receiving native type II collagen showed significant improvements in joint function, as measured by the WOMAC function scores. This includes better performance in activities such as ascending stairs and walking on flat surfaces1 3 5.

Range of Motion: Enhanced knee flexibility and mobility were observed, with significant improvements in knee passive range of motion and other motor functions9 10.

Quality of Life

SF-36 and EQ-5D Scores: Quality of life, particularly in the physical domain, improved significantly for patients treated with native type II collagen. This was reflected in better scores on the SF-36 and EQ-5D questionnaires1 4 6.

JKOM and JLEQ Scores: Additional studies reported improvements in the Japan Knee Osteoarthritis Measure (JKOM) and Japan Low Back Pain Evaluation Questionnaire (JLEQ), indicating better overall joint health and reduced discomfort9.

Biochemical Markers

Cartilage Degradation Markers: While some studies did not find significant improvements in biochemical markers of cartilage degradation, the overall clinical benefits were evident in symptom relief and functional improvements1.

Safety and Tolerability

Adverse Effects: Native type II collagen was well-tolerated across studies, with no significant adverse effects reported. This makes it a safe option for long-term use in managing OA symptoms5 6 9.

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Common Complaints Associated with Collagen Type II (Native) Use

Gastrointestinal Issues

One of the most frequently reported complaints with the use of Collagen Type II (Native) is gastrointestinal discomfort. This can include symptoms such as bloating, gas, and stomach cramps. These issues are generally mild but can be bothersome for some users.

Allergic Reactions

Although rare, some individuals may experience allergic reactions to Collagen Type II (Native). Symptoms can range from mild skin rashes to more severe reactions like difficulty breathing. It is essential to consult a healthcare provider if any allergic symptoms occur.

Joint Pain

Ironically, some users report an increase in joint pain when they first start taking Collagen Type II (Native). This could be due to the body’s initial response to the supplement and may subside over time.

Headaches

Headaches are another less common but reported side effect. The exact mechanism is not well understood, but it could be related to the body’s adjustment to the new supplement.

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Disclaimer

The content presented in this blog is generated by Consensus, an AI-powered academic search engine, and is based on publicly available scientific literature. While every effort is made to provide accurate, up-to-date, and well-researched information, the content is intended for informational and educational purposes only. It does not constitute medical advice, diagnosis, or treatment. Always consult a qualified healthcare professional before making any decisions regarding medical conditions, treatments, or medications. The AI system’s analysis may not cover all perspectives, emerging research, or individual cases, and it is not a substitute for professional expertise. Neither the blog publisher nor the developers of the AI-powered search engine are responsible for any actions taken based on the information provided in this content. Use of this information is at your own risk. Citations to the original scientific studies are included for reference, but these studies should be reviewed in full and interpreted with the guidance of a healthcare or research professional.

If you are experiencing a medical emergency, please seek immediate attention from a healthcare provider.