What Is Diosmin? Other Names: Bioflavonoid Complex, Citrus Bioflavones, Diosmetin

What is Diosmin?

This post was written with Consensus AI Academic Search Engine – please read our Disclaimer at the end of this article. Diosmin is a naturally occurring flavonoid glycoside primarily found in citrus fruits. It is known for its various therapeutic properties, including anti-inflammatory, antioxidant, and venotonic effects. Diosmin is often used in the treatment of chronic venous insufficiency, hemorrhoids, and lymphedema due to its ability to improve venous tone and reduce capillary permeability. Other names include: 3′,5,7-trihydroxy-4′-methoxyflavone-7-rhamnoglucoside, Bioflavonoid, Bioflavonoid Complex, Bioflavonoid Concentrate, Bioflavonoid Extract, Bioflavonoïde, Bioflavonoïde d’Agrume, Bioflavonoïdes d’Agrumes, Citrus Bioflavones, Citrus Bioflavonoid, Citrus Bioflavonoids, Citrus Bioflavonoid Extract, Citrus Flavones, Citrus Flavonoids, Complexe de Bioflavonoïde, Concentré de Bioflavonoïde, Diosmetin, Diosmetin 7-O-rutinoside, Diosmina, Diosmine, Extrait de Bioflavonoïde, Extrait de Bioflavonoïde d’Agrume, Flavonoid, Flavonoïde, Micronised Purified Flavonoid Fraction.

Therapeutic Applications of Diosmin

Hepatoprotection

Diosmin has been shown to protect against liver damage induced by various toxic agents. For instance, it alleviates doxorubicin-induced liver injury by modulating oxidative stress and reducing inflammation and apoptosis through the NF-kB and MAPK pathways1. Similarly, diosmin mitigates ethanol-induced hepatic injury by alleviating inflammation and regulating TNF-α and NF-κB activation7.

Neuroprotection

Diosmin exhibits neuroprotective effects in models of cognitive impairment. It improves cognitive deficits and enhances brain electrical activity in traumatic brain injury models by reducing TNF-α levels in the hippocampus2. Additionally, diosmin protects against scopolamine-induced cognitive impairment by reversing synaptic plasticity disruptions and reducing hippocampal inflammation4.

Cardiovascular Benefits

Diosmin has been studied for its potential benefits in cardiovascular health. It shows protective effects against diabetic cardiomyopathy by reducing oxidative stress, inflammation, and apoptosis in cardiac tissues9. Furthermore, diosmin alters the metabolism of noradrenaline in varicose veins, suggesting its role in managing chronic venous insufficiency8.

Clinical Implications

Diosmin is widely used in clinical settings for its venotonic properties, particularly in the management of chronic venous disorders. Its ability to reduce swelling and pain post-surgery, such as after total knee arthroplasty, highlights its potential in improving postoperative recovery3. However, further studies are needed to fully understand its efficacy and safety in various therapeutic contexts.

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Diosmin Mechanisms of Action

Antioxidant and Anti-inflammatory Effects

Diosmin exerts its protective effects primarily through its antioxidant properties, which help in reducing oxidative stress markers and enhancing antioxidant enzyme activities. It also exhibits anti-inflammatory effects by downregulating pro-inflammatory cytokines such as TNF-α and interleukins6 9.

Modulation of Enzymatic Pathways

Diosmin influences various enzymatic pathways, including the modulation of ethanol metabolizing enzymes and the reduction of lipid peroxidation, which contributes to its protective effects against organ damage7 6.

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Adverse Effects of Diosmin

General Safety: Studies have shown that diosmin, even at high doses up to 2000 mg per day, does not cause significant adverse effects. Parameters such as blood count, liver enzymes, and kidney function remained stable, and no significant adverse reactions were reported in clinical trials8.

Lack of Adverse Effects in Animal Studies: In various animal studies, diosmin did not cause significant changes in biochemical or histological parameters when administered alone. For instance, in studies involving rats, diosmin did not alter oxidative stress markers or cause organ damage, suggesting a lack of toxicity1 2 3.

Clinical Trials: In human clinical trials, diosmin was found to be effective in reducing symptoms of conditions like radicular pain and chronic prostatitis without significant adverse reactions. The incidence of adverse effects was lower compared to control groups, indicating a favorable safety profile6 7.

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How has Diosmin Improved Patient Outcomes?

Chronic Venous Disease (CVD)

Diosmin significantly reduces leg edema and pain in patients with CVD, leading to improved quality of life. It also enhances clinical scores such as the Venous Clinical Severity Score (VCSS) and Global Index Score (GIS) without notable side effects1.

Post-Surgical Recovery

After total knee arthroplasty, diosmin effectively reduces lower-extremity swelling and pain during motion, although it does not significantly affect pain at rest or other functional outcomes2.

In hemorrhoidectomy patients, diosmin alleviates post-operative symptoms such as pain, heaviness, and bleeding, and shortens hospital stays3.

Deep Vein Thrombosis (DVT)

Diosmin, when used alongside rivaroxaban, enhances deep vein recanalization and reduces the incidence of post-thrombotic syndrome (PTS) in patients with femoropopliteal DVT4 6.

Radicular Pain

Diosmin provides significant relief from radicular pain, with high patient satisfaction and no adverse effects reported5.

Hemorrhoids

Diosmin improves symptoms of acute and chronic hemorrhoids, reducing the duration and intensity of symptoms such as bleeding and pain8 9.

Lymphedema

In combination with other therapies, diosmin contributes to the reduction of breast cancer-related lymphedema, improving limb volume and patient-reported outcomes10.

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Common Complaints Associated with Diosmin Use

Protective Effects: The study highlights diosmin’s ability to mitigate liver damage caused by doxorubicin, a chemotherapeutic agent. It does so by modulating oxidative stress and reducing inflammation and apoptosis in the liver1.

Antioxidant Restoration: Diosmin was shown to restore hepatic antioxidant factors and normalize serum enzymatic activities, which were disrupted by doxorubicin treatment1.

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Disclaimer

The content presented in this blog is generated by Consensus, an AI-powered academic search engine, and is based on publicly available scientific literature. While every effort is made to provide accurate, up-to-date, and well-researched information, the content is intended for informational and educational purposes only. It does not constitute medical advice, diagnosis, or treatment. Always consult a qualified healthcare professional before making any decisions regarding medical conditions, treatments, or medications. The AI system’s analysis may not cover all perspectives, emerging research, or individual cases, and it is not a substitute for professional expertise. Neither the blog publisher nor the developers of the AI-powered search engine are responsible for any actions taken based on the information provided in this content. Use of this information is at your own risk. Citations to the original scientific studies are included for reference, but these studies should be reviewed in full and interpreted with the guidance of a healthcare or research professional.

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