What Is Ligilactobacillus Salivarius? Other Names: L. salivarius, Lactobacillus salivarius, Probiotique

What is Ligilactobacillus Salivarius?

This post was written with Consensus AI Academic Search Engine – please read our Disclaimer at the end of this article. Ligilactobacillus salivarius is a species of probiotic bacteria that has garnered attention for its potential health benefits across various domains. It is a member of the Lactobacillus genus, known for its role in maintaining gut health and modulating the immune system. This article explores the diverse applications and benefits of Ligilactobacillus salivarius as evidenced by recent research studies. Other names include:  L. salivarius, Lactobacillus salivarius, Probiotic, Probiotique.

Health Benefits and Applications of Ligilactobacillus Salivarius

Gout and Hyperuricemia

Ligilactobacillus salivarius has shown promise in managing hyperuricemia and gout. A study demonstrated that the strain L. salivarius CECT 30632 could metabolize purine-related metabolites, leading to a reduction in serum urate levels and the frequency of gout episodes in patients with a history of hyperuricemia1. This suggests its potential as a therapeutic agent in managing gout.

Oral Health

The probiotic has also been studied for its effects on oral health. L. salivarius CCFM1215 was found to significantly reduce halitosis by decreasing volatile sulfur compounds and altering the oral microbiome, which includes reducing the abundance of harmful bacteria like Fusobacterium nucleatum2. Additionally, heat-killed L. salivarius CP3365 was effective in maintaining periodontal health by inhibiting the growth of oral pathogens4.

Asthma Management

In pediatric asthma, L. salivarius LS01, in combination with Bifidobacterium breve, was shown to reduce the frequency of asthma exacerbations, indicating its potential role in modulating immune responses and reducing inflammation3.

Gut Health in Animals

Ligilactobacillus salivarius has been used in animal studies to improve gut health. For instance, supplementation with L. salivarius PS21603 in weaned piglets optimized intestinal morphology and gut microbiota composition, reducing the prevalence of harmful bacteria like Escherichia coli5.

Pregnancy and Lactation

The strain L. salivarius V4II-90 was effective in eradicating Group B Streptococcus colonization during pregnancy, reducing the need for intrapartum antibiotic prophylaxis7. Furthermore, L. salivarius PS2 supplementation during pregnancy and lactation was shown to prevent mastitis, a common issue that can lead to breastfeeding cessation8.

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Adverse Effects of Ligilactobacillus Salivarius

Safety and Tolerance

General Safety: Ligilactobacillus salivarius strains, such as CECT5713 and V4II-90, have been shown to be nonpathogenic and safe for consumption in both animal and human studies, even at high doses1 3. No adverse events were directly linked to the probiotic in these studies.

Specific Populations: In preterm infants, supplementation with L. salivarius was well-tolerated, with no adverse events related to the probiotic intake6. Similarly, in children with asthma, the probiotic was safe and reduced asthma exacerbations9.

Administration and Effects

Oral Administration: Oral intake of L. salivarius in various forms, including heat-killed and live strains, has been associated with positive health outcomes without significant adverse effects4 5.

Intraperitoneal Administration: In mice, intraperitoneal administration led to bacterial translocation to the liver and spleen, but this was not associated with illness or death, suggesting that the method of administration can influence outcomes1.

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How has Ligilactobacillus Salivarius Improved Patient Outcomes?

Asthma Management

Reduction in Asthma Exacerbations: In children with asthma, a probiotic mixture including Ligilactobacillus salivarius significantly reduced the frequency of asthma exacerbations, suggesting its role as an auxiliary remedy alongside traditional drug-based treatments1.

Gout and Hyperuricemia

Decrease in Gout Episodes: Ligilactobacillus salivarius CECT 30632 was effective in reducing the number of gout episodes and the need for gout-related medications in hyperuricemic patients, also improving blood parameters related to oxidative stress and metabolic syndrome2.

Oral Health

Halitosis and Periodontal Health: Ligilactobacillus salivarius, alone or combined with inulin, significantly reduced halitosis and improved periodontal health by inhibiting harmful oral bacteria3 5 10.

Pregnancy and Neonatal Health

Reduction in GBS Colonization: During pregnancy, Ligilactobacillus salivarius V4II-90 significantly decreased Group B Streptococcus colonization, reducing the need for intrapartum antibiotic prophylaxis8.

Metabolic and Cardiovascular Health

Improvement in Lipid Profiles and Inflammatory Markers: Supplementation with Ligilactobacillus salivarius improved lipid profiles and reduced inflammatory markers in healthy individuals, with enhanced benefits when combined with prebiotics7.

Autism Spectrum Disorders

Behavioral and Gastrointestinal Improvements: In children with autism, a probiotic mixture including Ligilactobacillus salivarius improved gastrointestinal symptoms and behavioral outcomes, highlighting the gut-brain axis’s role in autism6.

Chronic Kidney Disease

Reduction in Uremic Toxins: In animal models of chronic kidney disease, Ligilactobacillus salivarius helped reduce serum levels of harmful uremic toxins, suggesting potential benefits for cardiovascular health9.

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Ligilactobacillus Salivarius Mechanisms of Action

Purine Metabolism: Ligilactobacillus salivarius can metabolize purine-related metabolites such as inosine, guanosine, and uric acid. This ability helps reduce serum urate levels and the frequency of gout episodes, as demonstrated in hyperuricemic patients1.

Antimicrobial Activity: Heat-killed Ligilactobacillus salivarius strains exhibit inhibitory effects against harmful oral bacteria, such as Porphyromonas gingivalis and Fusobacterium nucleatum. This action helps maintain periodontal health by reducing the abundance of these bacteria in the oral cavity2 5.

Anti-inflammatory Effects: In mouse models of colitis, Ligilactobacillus salivarius has shown intestinal anti-inflammatory effects. It helps restore microbiota balance and modulates immune responses, although its effects are less pronounced compared to other probiotics like Lactobacillus fermentum3.

Asthma Management: In children with asthma, Ligilactobacillus salivarius, when combined with Bifidobacterium breve, has been shown to reduce the frequency of asthma exacerbations. This suggests a role in modulating immune responses and potentially repairing gut and lung dysbiosis4.

Oral Health Improvement: Ligilactobacillus salivarius can alleviate halitosis by reducing volatile sulfur compounds and decreasing the quantity of harmful bacteria like Fusobacterium nucleatum in the oral cavity. This contributes to a more stable and beneficial oral microbiota5.

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Common Complaints Associated with Ligilactobacillus Salivarius Use

Safety and Efficacy

Hyperuricemia and Gout Management: In a study involving patients with hyperuricemia and recurrent gout episodes, Ligilactobacillus salivarius CECT 30632 was administered for six months. The results showed a significant reduction in gout episodes and an improvement in blood parameters related to oxidative stress and metabolic syndrome, indicating its efficacy and safety in this context1.

Pediatric Asthma Management: Another study focused on children with asthma using a probiotic mixture containing Ligilactobacillus salivarius LS01. The study found that this probiotic significantly reduced the frequency of asthma exacerbations and was deemed safe for use in children2.

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Disclaimer

The content presented in this blog is generated by Consensus, an AI-powered academic search engine, and is based on publicly available scientific literature. While every effort is made to provide accurate, up-to-date, and well-researched information, the content is intended for informational and educational purposes only. It does not constitute medical advice, diagnosis, or treatment. Always consult a qualified healthcare professional before making any decisions regarding medical conditions, treatments, or medications. The AI system’s analysis may not cover all perspectives, emerging research, or individual cases, and it is not a substitute for professional expertise. Neither the blog publisher nor the developers of the AI-powered search engine are responsible for any actions taken based on the information provided in this content. Use of this information is at your own risk. Citations to the original scientific studies are included for reference, but these studies should be reviewed in full and interpreted with the guidance of a healthcare or research professional.

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