What Is Long COVID (PASC)?

Understanding Long COVID (PASC)

This post was written with Consensus AI Academic Search Engine – please read our Disclaimer at the end of this article. Long COVID, also known as Post-Acute Sequelae of SARS-CoV-2 (PASC), refers to a range of symptoms that persist for weeks or months following the acute phase of a COVID-19 infection. These symptoms can affect multiple systems in the body, including neurological, cardiovascular, respiratory, gastrointestinal, autonomic nervous, and immune systems. Common non-specific symptoms include fatigue, headaches, and brain fog, which are not easily attributed to a single system1 4 5.

Pathophysiology

The underlying mechanisms of PASC are not fully understood, but it is believed to involve sustained inflammatory responses and immune dysregulation following the initial infection. This can lead to prolonged symptoms and complications such as microvascular thrombosis, which may contribute to the persistence of symptoms2 5 8.

Impact on Quality of Life

PASC significantly impacts patients’ quality of life, affecting their social, academic, and vocational functioning. It can also strain healthcare systems already burdened by acute COVID-19 cases. The symptoms can lead to disability and limit work capacity, further complicating recovery and rehabilitation efforts1 5 7.

Current Research and Treatments

Research is ongoing to find effective treatments for PASC. Some studies have explored the use of mesenchymal stromal cells (MSCs) for their immunomodulatory properties, which may help reduce post-acute sequelae in critically ill patients2. Other interventions, such as metformin, have shown promise in reducing the incidence of Long COVID when used as an early treatment3. Additionally, innovative approaches like transcutaneous auricular vagus nerve stimulation (taVNS) are being investigated for their potential to alleviate neuropsychiatric symptoms associated with Long COVID4.

Future Directions

The management of PASC requires a multifaceted approach, including self-management strategies and possibly telemedicine for ongoing care. Cardiological televisits, for example, are being evaluated for their feasibility and socio-economic impact in managing PASC symptoms9. As research progresses, it is crucial to continue exploring diverse treatment modalities and their efficacy in improving the quality of life for those affected by Long COVID.

In summary, Long COVID (PASC) is a complex condition with a wide range of symptoms affecting multiple body systems. It poses significant challenges to both patients and healthcare systems, necessitating ongoing research and innovative treatment strategies to mitigate its impact.

Disclaimer

The content presented in this blog is generated by Consensus, an AI-powered academic search engine, and is based on publicly available scientific literature. While every effort is made to provide accurate, up-to-date, and well-researched information, the content is intended for informational and educational purposes only. It does not constitute medical advice, diagnosis, or treatment. Always consult a qualified healthcare professional before making any decisions regarding medical conditions, treatments, or medications. The AI system’s analysis may not cover all perspectives, emerging research, or individual cases, and it is not a substitute for professional expertise. Neither the blog publisher nor the developers of the AI-powered search engine are responsible for any actions taken based on the information provided in this content. Use of this information is at your own risk. Citations to the original scientific studies are included for reference, but these studies should be reviewed in full and interpreted with the guidance of a healthcare or research professional.

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