What Is Rue? Other Names: Arvada, Herb-of-Grace, Ruta Graveolens

What is Rue?

This post was written with Consensus AI Academic Search Engine – please read our Disclaimer at the end of this article. Rue, scientifically known as Ruta graveolens L., is a medicinal herb renowned for its diverse therapeutic properties. Traditionally used in various cultures for its medicinal benefits, rue has been studied for its potential effects on biological processes, including its impact on reproductive health. Other names include: Arvada, Aruta, Common Rue, Garden Rue, German Rue, Herb-of-Grace, Herbe à la Belle-Fille, Herbe de Grâce, Herbe de Repentance, Herbe de la Rue, Herbygrass, Raute, Ruda, Ruda de Castilla, Rue Fétide, Rue des Jardins, Rue Officinale, Rue Puante, Ruta Grav, Ruta graveolens, Rutae Folium, Rutae Herba, Sadapaka, Satap, Sudabugida, Sudapa.

Medicinal Properties of Rue

Rue is primarily recognized for its anti-androgenic characteristics. This means it can influence hormonal activities, particularly those related to male reproductive hormones. The herb has been used in traditional medicine to address a range of health issues, from digestive problems to menstrual disorders.

Effects on Reproductive Health

Recent studies have explored the impact of rue on spermatogenesis, the process of sperm cell development. In a study involving guppy fish (Poecilia reticulata), rue was found to significantly affect male sexual parameters. The administration of rue ethanolic extract at varying doses resulted in a notable decrease in testosterone levels and sperm counts, particularly at higher doses of 10 and 100 mg.kg-11. This suggests that rue can inhibit certain aspects of male reproductive health, confirming its anti-androgenic properties.

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Rue Mechanism of Action

The study on guppies revealed that rue affects the development of spermatogenesis by reducing the formation of spermatozeugmata, which are clusters of sperm cells. Additionally, there was an observed increase in the number of spermatocytes, indicating a disruption in the normal progression of sperm development1. These findings highlight rue’s potential as a natural inhibitor of male reproductive functions.

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Uses of Rue

Antiparasitic Activity: Rue has been traditionally used for its antiparasitic properties, helping to combat parasitic infections1.

Antioxidant Properties: The plant exhibits antioxidant activity, which can help in reducing oxidative stress and potentially prevent damage to cells1.

Antibacterial Effects: Rue has been shown to possess antibacterial properties, making it useful in fighting bacterial infections1.

Allelopathic Activity: This refers to the plant’s ability to influence the growth and development of neighboring plants, which can be beneficial in agricultural settings for weed management1.

Antinociceptive Effects: Rue has demonstrated the ability to reduce pain perception in experimental models, particularly at certain dosages (50 mg/kg and 100 mg/kg). However, higher doses (500 mg/kg) may have the opposite effect, increasing pain perception1.

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Adverse Effects of Rue

Impact on Testosterone Levels: Rue has been shown to significantly lower whole-body testosterone levels in male guppies, particularly at higher doses (100 mg.kg-1) compared to control groups1.

Reduction in Sperm Count: Administration of Rue at doses of 10 and 100 mg.kg-1 results in a notable decrease in sperm counts, indicating its potential to impair fertility1.

Alteration in Gonopodial Index: Males treated with Rue at all tested doses exhibited a significantly lower gonopodial index, which is a measure of reproductive organ development in guppies1.

Histopathological Changes: Rue-fed animals showed a dose-dependent decrease in spermatozeugmata and an increase in spermatocytes’ number of ducts. This suggests that Rue can hinder the development of spermatogenesis, the process of sperm cell development1.

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How has Rue Improved Patient Outcomes?

Effects on Sperm Counts

In guppy males, administration of Rue ethanolic extract at doses of 10 and 100 mg/kg resulted in a significant reduction in sperm counts compared to the control group. This suggests a dose-dependent effect of Rue on reducing sperm production1.

Effects on Testosterone Levels

The study on guppy males also found that a dose of 100 mg/kg of Rue significantly lowered whole-body testosterone levels compared to the control group. This indicates that Rue can reduce testosterone levels, potentially affecting male reproductive health1.

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Common Complaints Associated with Rue

Side Effects and Complaints

Gastrointestinal Issues: Rue is commonly associated with gastrointestinal complaints such as nausea, vomiting, and stomach pain. These symptoms are often reported by individuals who consume rue in large quantities or without proper preparation.

Photosensitivity: One of the notable side effects of rue is photosensitivity, where the skin becomes more sensitive to sunlight, leading to an increased risk of sunburns. This is due to the presence of certain compounds in rue that can react with sunlight.

Allergic Reactions: Some individuals may experience allergic reactions to rue, which can manifest as skin rashes, itching, or more severe symptoms like difficulty breathing. It is important for users to be aware of any personal allergies to rue or related plants.

Neurological Effects: In some cases, rue has been reported to cause neurological symptoms such as dizziness or headaches. These effects are typically associated with high doses or prolonged use.

Risk Factors and Prevention

Dosage and Preparation: The risk of adverse effects from rue can be minimized by adhering to recommended dosages and ensuring proper preparation. Overconsumption or improper use increases the likelihood of experiencing negative side effects.

Individual Sensitivities: Individuals with known sensitivities or allergies to rue should avoid its use. It is advisable to conduct a patch test or consult with a healthcare provider before using rue, especially for those with a history of allergies.

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Disclaimer

The content presented in this blog is generated by Consensus, an AI-powered academic search engine, and is based on publicly available scientific literature. While every effort is made to provide accurate, up-to-date, and well-researched information, the content is intended for informational and educational purposes only. It does not constitute medical advice, diagnosis, or treatment. Always consult a qualified healthcare professional before making any decisions regarding medical conditions, treatments, or medications. The AI system’s analysis may not cover all perspectives, emerging research, or individual cases, and it is not a substitute for professional expertise. Neither the blog publisher nor the developers of the AI-powered search engine are responsible for any actions taken based on the information provided in this content. Use of this information is at your own risk. Citations to the original scientific studies are included for reference, but these studies should be reviewed in full and interpreted with the guidance of a healthcare or research professional.

If you are experiencing a medical emergency, please seek immediate attention from a healthcare provider.