Клинико-патогенетическая оценка сочетанного течения хронической обструктивной болезни легких и гастроэзофагеальной рефлюксной болезни
Я. М. Вахрушев, Э. Ш. Шаверская
2012
Citations
43
Citations
Quality indicators
Journal
Journal name not available for this finding
Full text
Semantic Scholar
Key Takeaway Key Takeaway: Common pathogenic factors, such as lipid peroxidation and hormone status, contribute to the co-morbidity of GERD and COPD in patients.
Abstract
Summary. The aim of this work was to study clinical peculiarities of gastro-esophageal reflux disease (GERD) in patients with chronic obstructive pulmonary disease (COPD) and pathogenic relationships of this co-morbidity. We examined 64 patients with COPD. Additionally to clinical examination, we performed esophagogastroduodenoscopy (EGDS), intraesophageal and intragastric pH-metry, investigated oxidation status, blood oxygen saturation using pulse oxymetry and hormonal status of patients. Results showed that the majority of patients (84.3 %) coughed after eating, in supine position and at night. Endoscopic examination revealed GERD signs in 53 patients (82.8 %). Gastric hyperacidity was found in 56 patients (87.5 %). Changes in intraesophageal pH were dependent on severity of COPD. We revealed correlations between malone dialdehyde concentration and oxygen saturation and severity of COPD. Pathogenic relationships found confirmed a role of hormones in co-morbidity of COPD and GERD. Our study results suggest that changes in lipid peroxidation and hormone status indicate a presence of common pathogenic factors in concomitant course of GERD and COPD.