Марина Акоповна Петросян, Н. Т. Товмасян, М. З. Нариманян
Journal name not available for this finding
The objective of this study was to investigate echocardiographic abnormalities in patients with obstructive sleep apnea syndrome (OSAS). Methods . The study involved 57 patients with OSAS and 22 healthy control subjects. Respiratory polygraphy and 2D Doppler echocardiography were performed. Apnea/hypopnea index (AHI) was used to quantify the OSAS severity. Both morphology (wall thickness, diameters) and function (ejection fraction, fractional shortening, peak E and A wave velocities, mitral deceleration time) were assessed. Patients with comorbidities which were known to affect the heart structure and function excepting arterial hypertension were excluded from the study. Results. The results showed that OSAS was associated with left ventricular diastolic dysfunction, left and right ventricular hypertrophy independently of severity. Additionally, severe OSAS could cause the left ventricular systolic dysfunction, enlargement the ascending aorta diameter and mild increase in the right ventricular systolic pressure. Comorbod arterial hypertension could deteriorate these structural and functional abnormalities in patients with OSAS. With increase in frequency of apnea and desaturation during sleep, the heart structural and functional parameters worsen.