Paper
1,4-Diazabicyclo[2.2.2]octane as an Efficient Catalyst for a Clean, One-Pot Synthesis of Tetrahydrobenzo[b]pyran Derivatives via Multicomponent Reaction in Aqueous Media
Published Jun 29, 2011 · D. Tahmassebi, Jessica A. Bryson, Sophia I. Binz
Synthetic Communications
86
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1
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Abstract
Abstract 1,4-Diazabicyclo[2.2.2]octane (DABCO) has been used as a mild and efficient catalyst for the synthesis of various tetrahydrobenzo[b]pyran derivatives via a one-pot, three component condensation of aromatic aldehydes, dimedone, and active methylene compounds. This method provides several advantages: a simple workup procedure, environmental friendliness, neutral conditions, and good yields. In addition, water or 50% aqueous ethanol was chosen as a green solvent. Graphical Abstract
1,4-Diazabicyclo[2.2.2]octane (DABCO) is an efficient catalyst for the synthesis of various tetrahydrobenzo[b]pyran derivatives in a one-pot, environmentally friendly manner using water or 50% aqueous ethanol as green solvent
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