2-Benzoyl-6-benzylidenecyclohexanone analogs as potent dual inhibitors of acetylcholinesterase and butyrylcholinesterase.

doi:10.1016/j.bmc.2016.06.016

Paper

DOI: 10.1016/j.bmc.2016.06.016

2-Benzoyl-6-benzylidenecyclohexanone analogs as potent dual inhibitors of acetylcholinesterase and butyrylcholinesterase.

Published Aug 15, 2016 · S. Leong, F. Abas, K. Lam

Bioorganic & medicinal chemistry

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Abstract

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In Vitro Study

Study Snapshot

2-benzoyl-6-benzylidenecyclohexanone analogs show potential as potent dual inhibitors of acetylcholinesterase and butyrylcholinesterase, with potential therapeutic potential for cognitive diseases like Alzheimer's.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

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