2-Thiophenecarboxylic acid: a hypoglycemic, antilipolytic agent with hypocalcemic and hypophosphatemic effects in rats.

doi:10.1210/ENDO-85-4-763

Paper

2-Thiophenecarboxylic acid: a hypoglycemic, antilipolytic agent with hypocalcemic and hypophosphatemic effects in rats.

Published Oct 1, 1969 · W. Lloyd, V. Fang, H. Wells

Endocrinology

Q1 SJR score

24

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0

Influential Citations

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Abstract

Marked hypocalcemia followed ip and sc (460 mg/kg) or oral (920 mg/kg) administration of 2-thiophenecar boxy lie acid to rats. The drug also caused a fall in serum phosphorus. The maximum decline in serum calcium occurred at 2 hr after drug administration. It was still at this low level (7.6 mg/100 ml) at 4 hr and had returned to the control level by 8 hr. The hypocalcemic effect of 2-thiophenecarboxylic acid was retained after removal of the parathyroid glands, both the parathyroid and thyroid glands, the kidneys or the pancreas, indicating that the presence of these organs is not necessary for its action. In parathyroidectomized rats, 2-thiophenecarboxylic acid antagonized completely the hypercalcemic effects of parathyroid hormone and vitamin D2. No overt toxicity to the drug was seen. The effects of 2-thiophenecarboxylic acid on mineral metabolism are similar in many ways to those produced by thyrocalcitonin. These results suggest that future studies of 2-thiophenecarboxylic acid and related compounds...

Non-RCT

Animal Study

Study Snapshot

2-thiophenecarboxylic acid is a hypoglycemic, antilipolytic agent with hypocalcemic and hypophosphatemic effects in rats, similar to those produced by thyrocalcitonin, without overt toxicity.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

Paper

2-Thiophenecarboxylic acid: a hypoglycemic, antilipolytic agent with hypocalcemic and hypophosphatemic effects in rats.

References

Citations

Thermochemical properties of three 2-thiophenecarboxylic acid derivatives

Three 2-thiophenecarboxylic acid derivatives show thermochemical properties similar to benzene derivatives, with 3-methyl-2-thiophenecarboxylic acid having the highest enthalpy of formation and 5-methyl-2-thiophenecarboxylic acid having the lowest enthal

Calcium Antagonists and Experimental Atherosclerosis

Organic calcium antagonists' role in preventing atherosclerosis in animals remains unclear, and their effectiveness in humans remains uncertain.

The Effect of 2-Thiophenecarbocylic Acid (TCA) on Fracture Callus in early stage of HEBP (EHDP) Induced Rachitic Rats

TCA combined with HEBP promotes calcification of newly formed bone and caltilage in fracture callus in early stage HEBP-induced rachitic rats.

The Effect of 2-Thiophenecarboxylic Acid on Growth Plate in the HEBP Induced Rachitic Rats

2-Thiophenecarboxylic acid promotes calcification in growth plate in HEBP-induced rachitic rats, similar to the effect of calcitonin.

Thionapthene-2-carboxylic acid: a new antihypercalcemic agent.

TNCA is a potent hypocalcemic agent with a rapid and prolonged effect, potentially benefiting treatment of hypercalcemia and excessive bone resorption.