4,6-Diamino-5-(4-methylbenzylidene)pyrimidin-2(5H)-one

doi:10.3390/M653

Paper

4,6-Diamino-5-(4-methylbenzylidene)pyrimidin-2(5H)-one

Published Jan 27, 2010 · Gricela Lobo, Jaime E. Charris, Margaret Valderrama

Molbank

Q4 SJR score

4

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Abstract

Abstract: A new compound, 4,6-diamino-5-(methylbenzylidene)pyrimidin-2(5 H )-one, was synthesized and its IR, 1 H NMR, 13 C NMR and MS spectroscopic data are presented. Keywords: 4,6-diamino-5-(4-methylbenzylidene)pyrimidin-2(5 H )-one; urea; antimicrobial activity Pyrimidines and their derivatives are considered an important group of compounds because of the diversity of biological activities associated with these systems. Among the activities reported for pyrimidines have been found antifolate [1], antimicrobial [2], leishmanicidal [3], anticonvulsant [4], anti-rubella [5], anti-HIV [6], calcium channel modulation [7], and selective hepatitis B virus inhibition [8]. In the specialized literature, we can find different articles on the synthesis of substituted pyrimidines and many detailed reviews have appeared [9–12]. Recently, the Biginelli reaction is a well-known multicomponent reaction involving a one-pot cyclocondensation of an aldehyde, a methylene active compound and urea/thiourea for the synthesis of pyrimidine derivatives [13–15]. Nevertheless, little attention is given to the synthesis and biological activity of the pyrimidine nucleus having the benzylidene group in position 5, close to amino groups at positions 4 and 6. We report here the synthesis and biological activity of 4,6-diamino-5-(4-methylbenzylidene)pyrimidin-2(5

Study Snapshot

This new compound, 4,6-diamino-5-(4-methylbenzylidene)pyrimidin-2(5H)-one, shows promising antimicrobial activity and potential for use in pharmaceuticals.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

Paper

4,6-Diamino-5-(4-methylbenzylidene)pyrimidin-2(5H)-one

References

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Citations

Synthesis and Antimicrobial Activity of New Pyrimidine Derivatives Incorporating 1H-Tetrazol-5-ylthio Moiety

New 4,6-dimethoxy pyrimidine derivatives with 1H-tetrazol-5-ylthio moiety show good antibacterial activity, comparable to standard antibiotics Penicillin, Ampicillin, and Erythromycin.

Síntesis y actividad antimicrobiana de derivados de 4,6-diaminopirimidinas análogos de citosina

Novel 4,6-diaminopyrimidines 2a-j, cytosine analogs, show antimicrobial activity against Gram-positive and Gram-negative bacteria and yeasts.