8-Hydroxyquinolines with the Potential for Long-Term Anticaries Activity: Design, Synthesis, and In Vitro Evaluation

doi:10.1177/00220345780570012401

Paper

8-Hydroxyquinolines with the Potential for Long-Term Anticaries Activity: Design, Synthesis, and In Vitro Evaluation

Published Jan 1, 1978 · D. Mirth, A. Chite, G. Schuster

Journal of Dental Research

Q1 SJR score

4

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0

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Abstract

8-Hydroxyquinolyl benzoate and 8-hydroxyquinolyl para-(fluorosulfonyl)benzoate have been synthesized and evaluated in vitro as antimicrobial and antiplaque agents. Both compounds inhibited the growth of cultures of the following genera: Streptococcus, Staphylococcus, Actinomyces, Lactobacillus, Veillonella, and Candida. Minimum inhibitory concentrations ranged from 0.98 to 62 μg/ml. Extracted human teeth pretreated with 1% solutions of either compound and rinsed with distilled water exhibited reduced in vitro plaque formation for 48 hours. These results indicate that the in vitro antiplaque activity of 8-hydroxyquinolines can be enhanced by attaching the appropriate side chain in the 8-position.

In Vitro Study

Study Snapshot

8-hydroxyquinolines show potential as long-term anticaries agents by inhibiting bacteria growth and reducing plaque formation in vitro.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

8-Hydroxyquinolines with the Potential for Long-Term Anticaries Activity: Design, Synthesis, and In Vitro Evaluation

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