9-cis retinoic acid — a better retinoid for the modulation of differentiation, proliferation and gene expression in human neuroblastoma

doi:10.1023/A:1005785431343

Paper

9-cis retinoic acid — a better retinoid for the modulation of differentiation, proliferation and gene expression in human neuroblastoma

Published 2004 · P. Lovat, H. Irving, A. Malcolm

Journal of Neuro-Oncology

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23

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1

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Abstract

To date, the clinical success of 13-cis or all-trans retinoic acid in the treatment of neuroblastoma has been disappointing. In vivo, 13-cis will isomerise to both all-trans and 9-cis retinoic acid, believed to be the main biologically-active isomers. In vitro studies with an N-type neuroblastoma cell line, SH SY 5Y, show that 9-cis is better than other isomers at both inducing morphological differentiation and inhibiting proliferation. RAR-β, a gene which may mediate retinoic acid responsiveness and be of prognostic significance, is also more-effectively induced by 9-cis retinoic acid. 9-cis and all-trans retinoic acid do not have synergistic effects on SH SY 5Y cell proliferation and gene expression. A retinoid X receptor (RXR)-specific analogue of 9-cis retinoic acid had similar effects on gene expression to 9-cis retinoic acid alone. In view of these results, 9-cis retinoic acid or stable analogues of this retinoid may have potential for the treatment of neuroblastoma.

Study Snapshot

9-cis retinoic acid shows potential for treating neuroblastoma by inducing differentiation and inhibiting proliferation, with potential synergistic effects with all-trans retinoic acid.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

Paper

9-cis retinoic acid — a better retinoid for the modulation of differentiation, proliferation and gene expression in human neuroblastoma

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Citations

Differentiating Neuroblastoma: A Systematic Review of the Retinoic Acid, Its Derivatives, and Synergistic Interactions

Retinoic acid shows promise in inducing differentiation in neuroblastoma cells, but its effectiveness is limited to minimal residual disease maintenance therapy.

Downregulation of MYCN oncogene by retinoic acid in neuroblastoma

Retinoic acid treatment improves survival rates in neuroblastoma patients by repressing MYCN expression, with Rb acting as a connector for the real repressor at the MYCN promoter.

β-cyclodextrin nanosponges as multifunctional ingredient in water-containing semisolid formulations for skin delivery.

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