Paper
[(9-Fluorenylmethyl)oxy]carbonyl (Fmoc) amino acid chlorides in solid-phase peptide synthesis
Published Apr 1, 1991 · L. A. Carpino, H. Chao, M. Beyermann
Journal of Organic Chemistry
54
Citations
0
Influential Citations
Abstract
It is shown in this work that FMOC amino acid chlorides are also applicable to solid-phase syntheses by the simple expedient of in situ conversion to the appropriate N-hydroxybenzotriazole ester via reaction with a 1:1 mixture of HOBt and an appropriate tertiary amine. In cases where acid chlorides are inaccessible due to side-chain incompatibility, pentafluorophenyl esters or BOP-induced couplings represent convenient spot substitutes
FMOC amino acid chlorides can be effectively used in solid-phase peptide synthesis by in situ conversion to N-hydroxybenzotriazole ester and BOP-induced couplings.
Full text analysis coming soon...