In the second period she received a single dose of 500 ml. of normal gastric juice which was neutralized, incubated for one hour with 50 ,ug. of vitamin B12, kept at 50 C. for seven hours, and given by stomach tube eight hours after the last meal and eight hours before breakfast. Reticulocytes rose to a second peak of 7.4% on the sixth and seventh days, and this time the improvement in the anaemia was sustained.

Vitamin B12 administration into the buccal cavity, into a washed segment of the intestine, or after partial sterilization of the bowel can effectively improve pernicious anaemia and maintain reticulocyte levels.

British Medical Journal

Absorption of Vitamin B12 in Pernicious Anaemia: IV. Administration into Buccal Cavity, into Washed Segment of Intestine, or after Partial Sterilization of Bowel

Paper

Absorption of Vitamin B12 in Pernicious Anaemia: IV. Administration into Buccal Cavity, into Washed Segment of Intestine, or after Partial Sterilization of Bowel

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