Acetylation of Phenols, Anilines, and Thiols Using Silica Sulfuric Acid under Solvent-Free Conditions
D. Habibi, Payam Rahmani, Z. Akbaripanah
2013
Citations
8
Citations
Journal
Journal of Chemistry
Full text
Semantic Scholar
Key Takeaway Key Takeaway: Silica sulfuric acid effectively catalyzes acetylation of phenols, amines, and thiols under solvent-free conditions, with preferential selectivity for amino group acetylation in the presence of hydroxyl group.
Abstract
Silica sulfuric acid was employed as a heterogeneous catalyst for the acetylation of a variety of phenols, amines, and thiols under solvent-free conditions at room temperature. Deactivated substrates also acetylated rapidly, and the method showed the preferential selectivity for acetylation of amino group in the presence of hydroxyl groupinwhich no C-acylation was observed.
Text copied to clipboard
copied to clipboard