I. Mohan, B. Kumar, S. A. Khan
Jun 15, 2019
International Journal of Clinical Biochemistry and Research
Introduction: Diabetic nephropathy has become the single most important cause of end stage renal disease worldwide. Detection of early stages of diabetic nephropathy with sensitive tests may be useful to prevent progression of nephropathy. The present study was undertaken to study the serum sialic acid levels and microalbuminuria and to assess whether there is a relationship between these two with glycemic control and other parameters in diabetic nephropathy patients. Materials and Methods: A total number of 100 subjects participated in present study including 50 clinically diagnosed cases of type-2 diabetic nephropathy patients. Fasting and post-prandial blood sugar, urea, creatinine, serum sialic acid and urinary microalbumin levels were estimated. Results: The mean fasting blood sugar values in cases (181.40±45.82) as compared to controls (89.62±12.53) is statistically significant (p Conclusion: Estimation of serum sialic acid prior to microalbumin in diabetic patients is helpful in assessing the glycemic control and identify the risk of nephropathy which is the main cause for mortality and morbidity among type-2 diabetes mellitus patients. Keywords: Serum sialic acid, Microalbumin, HbA1c, Nephropathy, Type-2 diabetes mellitus.