Action of the carcinogen 7-bromomethylbenz(a)anthracene on synthetic polynucleotides.

doi:10.1111/J.1432-1033.1971.TB01450.X

Paper

Action of the carcinogen 7-bromomethylbenz(a)anthracene on synthetic polynucleotides.

Published Jul 1, 1971 · F. Pochon, A. Michelson

European journal of biochemistry

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20

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Abstract

The action of 7-bromomethylbenz[a]anthracene on polyguanylic acid has been examined. Alkaline hydrolysis of the product gives monomers substituted at C-8 of the guanine. The carcinogen also reacts with adenine residues in polynucleotides. In both cases polymers which are fluorescent at 20 °C in aqueous solution are obtained. The reactivity of a variety of ribo- and deoxyribopolynucleotides has been compared, and factors (particularly helix conformation) governing substitution at C-8 of purines in polynucleotides discussed. Some physical properties of the modified polymers, particularly fluorescence characteristics, are described. The influence of helix geometry on fluorescence polarisation of the conjugates is discussed.

Study Snapshot

7-bromomethylbenz(a)anthracene produces fluorescent polymers by reacting with guanine and adenine residues in synthetic polynucleotides, affecting their physical properties and fluorescence polarisation.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

Action of the carcinogen 7-bromomethylbenz(a)anthracene on synthetic polynucleotides.

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