M. Rasulov, M. Nurbekov, S. Bobkova
Oct 23, 2010
Pharmaceutical Chemistry Journal
The experiments reported here demonstrated that prophylactic use of trecrezan delayed the development of atherosclerosis in rabbits, with decreases in aortic atherosclerotic plaques and reductions in cholesterol, triacylglycerols, and β-lipoprotein levels in serum, liver, and aortic tissue. Trecrezan accelerated the synthesis of tryptophanyl tRNA synthetase, which is the key component in the complex mechanism of action of this agent.