Activation of estrous behavior in ovariectomized rats by intracerebral implants of estradiol benzoate.

doi:10.1210/ENDO-101-6-1716

Paper

Activation of estrous behavior in ovariectomized rats by intracerebral implants of estradiol benzoate.

Published Dec 1, 1977 · R. J. Barfield, J. Chen

Endocrinology

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206

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1

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Abstract

There is a lack of agreement among several studies on the site of action of estradiol in the regulation of estrous behavior in mammals in general, and in rats in particular. Two experiments were performed in an attempt to clarify this issue. In the first experiment, 29 ovariectomized rats received unilateral 27 gauge implants of estradiol benzoate (EB) in various areas of the brain. Animals were tested over a three week period for estrous responses to an intact male rat. The greatest response resulted from implants in the ventromedial hypothalamus (VMH). Implants in the preopticanterior hypothalamic region (POA-AH) and other areas of the brain were significantly less effective, but when progesterone (P) was given almost all animals responded, and the magnitude of responses did not differ among the various groups. In the second experiment 30 gauge tubing with EB in the lumen was employed in order to restrict the effective dose of hormone delivered to the brain. Implants were placed in the VMH, POA-AH, or i...

Non-RCT

Animal Study

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Study Snapshot

Intracerebral implants of estradiol benzoate in the ventromedial hypothalamus effectively activate estrous behavior in ovariectomized rats, with progesterone acting as a cofactor.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

Activation of estrous behavior in ovariectomized rats by intracerebral implants of estradiol benzoate.

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