Biological activity evaluation and action mechanism of 1,4-Pentadien-3-one derivatives containing thiophene sulfonate

doi:10.1080/10426507.2019.1655418

Paper

Biological activity evaluation and action mechanism of 1,4-Pentadien-3-one derivatives containing thiophene sulfonate

Published Feb 1, 2020 · T. Guo, Rongjiao Xia, Meihang Chen

Phosphorus, Sulfur, and Silicon and the Related Elements

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Abstract

Abstract A series of novel 1,4-pentadien-3-one derivatives containing a thiophene sulfonate group were designed, synthesized, and their antibacterial activities were assessed. Antibacterial bioassays indicated that some of the title compounds exerted significant bioactivities against Xanthomonas axonopodis pv. Citri (Xac), Ralstonia solanacearum (Rs) and Xanthomonas oryzae pv. Oryzae (Xoo). Especially for Xac, the value of minimum 50% effective concentration (EC50) of compound 4-((1E,4E)-5-(3-nitrophenyl)-3-oxopenta-1,4-dien-1-yl)phenylthiophene-2-sulfonate (3k) is 11.0 μg/mL, which is significantly superior to bismerthiazol (BT) (51.6 µg/mL) and thiodiazole-copper (TC) (94.7 µg/mL). Meanwhile, the mechanism of action of compound 3k was confirmed by using scanning electron microscopy (SEM). These results suggested that 1,4-pentadien-3-one derivatives containing thiophene sulfonate group may be considered as activators in the design of antibacterial agents. Graphical Abstract

Study Snapshot

1,4-pentadien-3-one derivatives containing thiophene sulfonate show significant antibacterial activities against Xanthomonas axonopodis pv. Citri, Ralstonia solanacearum, and Xanthomona

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

Biological activity evaluation and action mechanism of 1,4-Pentadien-3-one derivatives containing thiophene sulfonate

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