Addition of nitroalkanes to ortho-halo-nitrobenzenes: A new synthesis of 4-chloro-7-(trifluoromethyl)quinoline.

doi:10.1016/S0040-4039(00)88734-1

Paper

Addition of nitroalkanes to ortho-halo-nitrobenzenes: A new synthesis of 4-chloro-7-(trifluoromethyl)quinoline.

Published 1990 · J.Gregory Reid, Jean H Reny Runge

Tetrahedron Letters

Q3 SJR score

8

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0

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Abstract

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Study Snapshot

This study presents a new synthesis of 4-chloro-7-(trifluoromethyl)quinoline, an intermediate in the synthesis of the antihypertensive agent losulazine, with high yield and a simple procedure.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

Paper

Addition of nitroalkanes to ortho-halo-nitrobenzenes: A new synthesis of 4-chloro-7-(trifluoromethyl)quinoline.

References

Citations

Engineering another class of anti-tubercular lead: Hit to lead optimization of an intriguing class of gyrase ATPase inhibitors.

A quinoline scaffold led to a potent anti-tubercular lead with promising efficacy in enzyme and whole cell screening assays, offering potential for further optimization.

Arylation of nitromethane: masked nucleophilic formylation of fluoroquinolones

Arylation of nitromethane with fluoroquinolones under mild conditions produces excellent yields and easily transforms into aryl aldehyde, a process equivalent to nucleophilic formylation.

New synthesis of 2-trifluoromethyl-2,3-dihydro-1H-quinolin-4-ones

This study presents a new synthesis of 2-trifluoromethyl-2,3-dihydro-1H-quinolin-4-ones using N-(1-ethoxy-2,2,2-trifluoroethyl)anilines and diethyl malonate in high yields.

Recent synthetic developments in the nitro to carbonyl conversion (Nef reaction)

The Nef reaction, a key synthetic tool, has shown significant progress in synthesis of structurally-defined compounds by converting nitroalkanes into nitronate anions, which can act as carbon nucleophiles with various electrophiles.