New antiarrhythmic agents. 7. 2,3-Diaminopropionanilides.

doi:10.1021/JM00141A008

Paper

New antiarrhythmic agents. 7. 2,3-Diaminopropionanilides.

Published Sep 1, 1981 · P. Tenthorey, H. J. Adams, G. Kronberg

Journal of medicinal chemistry

Q1 SJR score

9

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0

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Abstract

A series of 2,3-diaminopropionanilides was synthesized by acylation of mono- and disubstituted aniline derivatives with 2,3-dibromopropionyl chloride and subsequent amination with the appropriate secondary amines. The target compounds were evaluated in mice for antiarrhythmic efficacy against chloroform-induced tachycardia and for central nervous system toxicity. Several of the active agents were found to have much higher antiarrhythmic potencies than lidocaine, but they were also toxic. Evaluation of the target compounds for local anesthetic activity in the form of sciatic nerve block in rats showed that most compounds had durations of block similar to that of lidocaine; none exhibited the long duration of block seen with etidocaine.

Non-RCT

Animal Study

Study Snapshot

2,3-diaminopropionanilides show higher antiarrhythmic potencies than lidocaine, but also toxicity, with most showing similar local anesthetic durations to lidocaine.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

New antiarrhythmic agents. 7. 2,3-Diaminopropionanilides.

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