Alkylation of 3-Ethoxy-2-Lithioacrylonitrile: Synthesis of 5-Alkylcytosines
David Smirnow, P. B. Hopkins
Aug 1, 1986
Citations
4
Citations
Journal
Synthetic Communications
Full text
Semantic Scholar
Key Takeaway Key Takeaway: 3-ethoxyacrylonitrile is a cost-effective precursor for the synthesis of 5-alkylcytosines, with modest yield when exposed to sodium ethoxide and urea in ethanol.
Abstract
Abstract The utility of commercially available, inexpensive 3-ethoxyacrylonitrile (1) as a precursor for the synthesis of 5-alkylcytosines was investigated. Metalation of 1 affords a 2-lithio derivative of sufficient stability to allow alkylation with allylic or benzylic bromides and primary iodides which are unbranched at the β-position. The alkylated derivatives are converted to 5-alkylcytosines in modest yield by exposure to sodium ethoxide and urea in ethanol.
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