Ultrastructural alterations of the glomeruli after prolonged immunization. Correlation with urinary excretion of kidney specific antigens in the rat.
E. Rosenmann, T. Dishon, J. Boss
Jul 1, 1973
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Beitrage zur Pathologie
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Key Takeaway Key Takeaway: Prolonged immunization in rats leads to ultrastructural alterations in the glomeruli, but chronic glomerulonephritis did not develop.
Abstract
Summary Kidney specimens of rats injected every 3rd day with 20 mg of BSA for 9–15 months were examined. Immunohistologically, deposition of rat gammaglobulin and avidity for heterologous complement were demonstrated in a mesangial pattern. Mesangial increase was found by light microscopy. Electronmicroscopically, matrix increase and electron dense deposits were noted in the mesangium in a segmental distribution. Subendothelial accumulations of loose coarsely granular material were also observed. Kidney specific antigens were more often detected in the urine during the early phase than in the late phase. Chronic glomerulonephritis did not develop despite prolonged administration of antigen and the renal findings are indicative of sequelae of a glomerulonephritic process. The pathogenesis and significance of these findings are discussed.