Angiogenesis induced by "normal" human breast tissue: a probable marker for precancer.
Published Oct 15, 1982 · H. Jensen, Ibsen Chen, Martin R. Devault
Science
133
Citations
1
Influential Citations
Abstract
Normal human breast lobules, freshly isolated by precision microdissection of tissue stained with methylene blue chloride, were assayed for their ability to induce neovascularization (angiogenesis) in rabbit irises. Histologically, normal lobules from cancerous breast induced angiogenesis twice as often as lobules from noncancerous breasts, suggesting that preneoplastic transformation is diffuse.
Study Snapshot
Key takeawayNormal human breast tissue can induce angiogenesis twice as often as noncancerous breast tissue, suggesting preneoplastic transformation is diffuse.
PopulationOlder adults (50-71 years)
Sample size24
MethodsObservational
OutcomesBody Mass Index projections
ResultsSocial networks mitigate obesity in older groups.