Anticancer activity in 2-methoxy-4-((4-methoxy-phenilimino)-methyl)-phenol compound on T47D breast cancer cells

doi:10.1088/1755-1315/456/1/012014

Paper

Anticancer activity in 2-methoxy-4-((4-methoxy-phenilimino)-methyl)-phenol compound on T47D breast cancer cells

Published Apr 8, 2020 · L. Sukria, E K Hayati, A. Hanapi

IOP Conference Series: Earth and Environmental Science

UNKNOWN SJR score

0

Citations

0

Influential Citations

Full textSemantic Scholar

Abstract

2-methoxy-4-((4-methoxyphenilimino)-methyl)-phenol compound is a Schiff base compound synthesized from vanillin and p-anisidin. The purpose of this research is to determine the stability of the 2-methoxy-4-((4-methoxyphenilimino) methyl) phenol compound and to test the anticancer activity of 2-methoxy-4-((4-methoxyphenilimino) methyl) phenol in inhibiting T47D breast cancer cells. The stability of the 2-methoxy-4-((4-methoxy-phenylimino)-methyl)- phenol compound was carried out by characterization using chemical tests, identification using FTIR and GC-MS. While the anticancer activity test of compound 2-methoxy-4-((4- methoxifenilimino) methyl) phenol using the MTT method. The results of re-characterization using chemical tests, identification of FTIR and KG-SM showed the compound was still stable. The IC50 value of compound 2-methoxy-4-((4-methoxyphenilimino) methyl) phenol was 353,038 μg/mL which showed weak activity in inhibiting T47D breast cancer cells.

In Vitro Study

Study Snapshot

The 2-methoxy-4-((4-methoxyphenilimino)-methyl)-phenol compound shows weak anticancer activity against T47D breast cancer cells, but its stability remains intact.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

Anticancer activity in 2-methoxy-4-((4-methoxy-phenilimino)-methyl)-phenol compound on T47D breast cancer cells

References

Citations