The comparative anticholinergic activity of a series of derivatives of 3-hydroxy piperidine.

doi:10.1002/JPS.3030431013

Paper

The comparative anticholinergic activity of a series of derivatives of 3-hydroxy piperidine.

Published Oct 1, 1954 · J. P. Long, H. Keasling

Journal of the American Pharmaceutical Association. American Pharmaceutical Association

UNKNOWN SJR score

14

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Abstract

Fourteen 3-hydroxy piperidine analogs have been compared to atropine and similar drugs for anticholinergic activity in six tests involving dog, rat, and rabbit. Two of these analogs, JB-323 (N-ethyl-3-hydroxy iperidine benzilate methobromide) and JB-340 (N-methyl-3-hydroxy piperidine Lnzilate methobromide), are approximately as active as atropine. The 3-hydroxy piperidines, in general, are relatively more active on the intestinal preparations than in inhibiting acetylcholine depressor responses, pilocarpine induced salivation, or β-methacholine induced lacrimation.

Non-RCT

Animal Study

Study Snapshot

Three-hydroxy piperidine analogs, JB-323 and JB-340, show anticholinergic activity similar to atropine, with more activity in the intestinal tract than in inhibiting acetylcholine depressor responses, salivation, or -methacholine induced lacrimation

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

The comparative anticholinergic activity of a series of derivatives of 3-hydroxy piperidine.

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