Anticonvulsant and proconvulsant properties of a series of structural isomers of piperidine dicarboxylic acid

doi:10.1016/0028-3908(84)90257-0

Paper

DOI: 10.1016/0028-3908(84)90257-0

Anticonvulsant and proconvulsant properties of a series of structural isomers of piperidine dicarboxylic acid

Published Apr 1, 1984 · M. Croucher, B. S. Meldrum, J. Collins

Neuropharmacology

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Abstract

Abstract hidden due to publisher request; this does not indicate any issues with the research. Click the full text link above to read the abstract and view the original source.

Non-RCT

Animal Study

Study Snapshot

Piperidine dicarboxylic acid can protect against sound-induced seizures, while its convulsant effects can cause myoclonus or convulsions, with their effects influenced by N-methyl-d-aspartate receptors.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

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Citations

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The NMDA receptor complex as a therapeutic target in epilepsy: a review

NMDAR antagonists show potential as antiepileptic drugs due to their involvement in epilepsy pathophysiology and potential for use in clinical trials and animal models.

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NMDA receptors: the first decade

NMDA receptors and their antagonists have revolutionized drug discovery, with potential therapeutic applications and a decade of research under their belt.

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Developmental changes in seizure susceptibility in carbonic anhydrase II-deficient mice and normal littermates.

Carbonic anhydrase II deficiency in mice increases resistance to clonic seizures and reduces mortality at ages 19-40 days, with anticonvulsant effects depending on seizure model and seizure type.

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Anticonvulsant effects of some calcium entry blockers in DBA/2 mice

Some calcium entry blockers show anticonvulsant effects in DBA/2 mice, suggesting potential use in human epilepsy treatment.

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