Antifungal properties of 3-methyl-5-aminoisoxazole-4-thiocyanate on four yeasts: an unusual dose-dependent effect on Rhodotorula glutinis Harrison

doi:10.1139/M96-029

Paper

Antifungal properties of 3-methyl-5-aminoisoxazole-4-thiocyanate on four yeasts: an unusual dose-dependent effect on Rhodotorula glutinis Harrison

Published Feb 1, 1996 · D. Mares, C. Romagnoli, A. Donini

Canadian Journal of Microbiology

Q2 SJR score

2

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Abstract

The antifungal activity of 3-methyl-5-aminoisoxazole-4-thiocyanate was studied on Candida albicans, Saccharomyces cerevisiae, Schizosaccharomyces pombe, and Rhodotorula glutinis. A significant inhibition of growth was evident in all yeasts. The ultrastructural modifications have demonstrated that the compound at half-minimum inhibitory concentration (MIC) dose (1.25 kg. mL-1) causes the transformation of R. glutinis from yeast to mycelium form by the formation of a germ tube. The accumulation of abnormal amounts of wall substances after treatment with the MIC is discussed in relation to ergosterol and chitin production.

In Vitro Study

Study Snapshot

3-methyl-5-aminoisoxazole-4-thiocyanate effectively inhibits yeast growth and causes Rhodotorula glutinis to transform into mycelium form, with a dose-dependent effect on this yeast.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

Antifungal properties of 3-methyl-5-aminoisoxazole-4-thiocyanate on four yeasts: an unusual dose-dependent effect on Rhodotorula glutinis Harrison

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