Anti-inflammatory properties of cytochrome P450 epoxygenase-derived eicosanoids.

doi:10.1126/SCIENCE.285.5431.1276

Paper

Anti-inflammatory properties of cytochrome P450 epoxygenase-derived eicosanoids.

Published Aug 20, 1999 · Koichi Node, Yuqing Huo, Xiu-Lu Ruan

Science

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1,161

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57

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Abstract

The epoxyeicosatrienoic acids (EETs) are products of cytochrome P450 epoxygenases that have vasodilatory properties similar to that of endothelium-derived hyperpolarizing factor. The cytochrome P450 isoform CYP2J2 was cloned and identified as a potential source of EETs in human endothelial cells. Physiological concentrations of EETs or overexpression of CYP2J2 decreased cytokine-induced endothelial cell adhesion molecule expression, and EETs prevented leukocyte adhesion to the vascular wall by a mechanism involving inhibition of transcription factor NF-kappaB and IkappaB kinase. The inhibitory effects of EETs were independent of their membrane-hyperpolarizing effects, suggesting that these molecules play an important nonvasodilatory role in vascular inflammation.

Highly Cited

Study Snapshot

Cyp2J2 cytochrome P450 epoxygenase-derived eicosanoids play a nonvasodilatory role in vascular inflammation by inhibiting NF-kappaB and IkappaB kinase, independent of their membrane-hyperpolarizing effects

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

Paper

Anti-inflammatory properties of cytochrome P450 epoxygenase-derived eicosanoids.

References

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Epoxyeicosatrienoic acids and dihydroxyeicosatrienoic acids are potent vasodilators in the canine coronary microcirculation.

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Epoxyeicosatrienoic acids (EET) play a role in vascular cell function beyond endothelium-derived hyperpolarization, with potential CYP mono/epoxygenases playing a role in their formation.

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CYP2J3 is a novel cytochrome P450 that plays a crucial role in cardiac contractility recovery after global ischemia, with potential therapeutic applications in heart failure.

Citations

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Oxylipins show potential in predicting recurrent major adverse cardiovascular events after STEMI and may serve as potential therapeutic targets.

Aerosolized Harmful Algal Bloom Toxin Microcystin-LR Induces Type 1/Type 17 Inflammation of Murine Airways

Aerosolized microcystin-LR from harmful algal blooms can trigger harmful airway inflammation in C57BL/6 mice, while BALB/c mice show no significant inflammation.

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Aerobic exercise alleviates statin-induced PCSK9 upregulation by increasing epoxyeicosatrienoic acid levels through the FoxO3a-Sirt6 axis.

Aerobic exercise can effectively reduce statin-induced PCSK9 upregulation, improving LDL-C levels and potentially enhancing the effectiveness of sEH inhibitors in atherosclerotic cardiovascular disease treatment.