New antiprotozoal agents: Synthesis and biological evaluation of different 4-(7-chloroquinolin-4-yl) piperazin-1-yl)pyrrolidin-2-yl)methanone derivatives.

doi:10.1016/j.bmcl.2016.12.043

Paper

New antiprotozoal agents: Synthesis and biological evaluation of different 4-(7-chloroquinolin-4-yl) piperazin-1-yl)pyrrolidin-2-yl)methanone derivatives.

Published Feb 1, 2017 · M. Ansari, F. Hayat, Afreen Inam

Bioorganic & medicinal chemistry letters

Q2 SJR score

3

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Abstract

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In Vitro Study

Study Snapshot

4-(7-chloroquinolin-4-yl) piperazin-1-yl)pyrrolidin-2-yl)methanone derivatives show promising antiamoebic activity and antimalarial activity, but are less effective and more toxic than quinine against human kidney epithelial

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

New antiprotozoal agents: Synthesis and biological evaluation of different 4-(7-chloroquinolin-4-yl) piperazin-1-yl)pyrrolidin-2-yl)methanone derivatives.

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