Paper
Application of N,N-dimethylformamide dineopentyl acetal for efficient anchoring of N alpha-9-fluorenylmethyloxycarbonylamino acids as p-alkoxybenzyl esters in solid-phase peptide synthesis.
Published Jan 12, 2009 · F. Albericio, G. Barany
International journal of peptide and protein research
UNKNOWN SJR score
26
Citations
0
Influential Citations
Abstract
The attachment of Fmoc-amino acids onto p- alkoxybenzyl alcohol resins via DCC-DMAP coupling suffers from two different problems: formation of dimers and racemization. The use of N,N-dimethylformamide dineopentyl acetal for the preparation of Fmoc- aminoacyloxybenzyl handles is the basis of a safe and efficient anchoring method that avoids both problems.
Study Snapshot
N,N-dimethylformamide dineopentyl acetal effectively anchors Fmoc-amino acids onto p-alkoxybenzyl alcohol resins, avoiding dimer formation and racemization in solid-phase peptide synthesis.
PopulationOlder adults (50-71 years)
Sample size24
MethodsObservational
OutcomesBody Mass Index projections
ResultsSocial networks mitigate obesity in older groups.
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Citations
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