Appraisal of Codeine as an Analgesic in Older Patients *

doi:10.1111/J.1532-5415.1978.TB03337.X

Paper

Appraisal of Codeine as an Analgesic in Older Patients *

Published Nov 1, 1978 · RUSSELL NO Yes, P. Jochimsen

Journal of the American Geriatrics Society

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Abstract

ABSTRACT: In an investigation of a new oral analgesic agent, codeine was chosen as the reference drug because of its established reputation as an effective agent for the relief of pain. Thirty‐five patients with cancer pain were studied. Their average age was 58 years. During a 5‐day hospital stay they received, on each of three days, either codeine (120 mg or 60 mg) or placebo. At hourly intervals after ingestion the nurse observer collected data on pain intensity and the degree of pain relief, and the patients independently charted the hourly intensity. Statistical analysis failed to show any significant superiority of either dose of codeine over placebo. Moreover, codeine is known to have a constipating effect. Re‐appraisal of the value of codeine as an analgesic agent in elderly patients seems justified.

RCT

Study Snapshot

Codeine showed no significant pain relief advantage over placebo in elderly cancer patients, and may have constipating effects.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

Appraisal of Codeine as an Analgesic in Older Patients *

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