Paper
Mitotic arrest of breast cancer MDA-MB-231 cells by a halogenated thieno[3,2-d]pyrimidine.
Published Apr 15, 2015 · Christina R. Ross, Kartik W Temburnikar, G. M. Wilson
Bioorganic & medicinal chemistry letters
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Abstract
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Study Snapshot
Halogenated thieno[3,2-d]pyrimidines can modify the cytotoxic mechanism of breast cancer MDA-MB-231 cells, affecting cell cycle status and cytotoxicity in a cell type-specific manner.
PopulationOlder adults (50-71 years)
Sample size24
MethodsObservational
OutcomesBody Mass Index projections
ResultsSocial networks mitigate obesity in older groups.
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References
Antiproliferative activities of halogenated thieno[3,2-d]pyrimidines.
Halogenated thieno[3,2-d]pyrimidines show antiproliferative activity against various cancer cell lines and show selective activity against various fungi.
2014·33citations·Kartik W Temburnikar et al.·Bioorganic & medicinal chemistry
Bioorganic & medicinal chemistry
Metrics other than potency reveal systematic variation in responses to cancer drugs.
Other parameters than potency should be considered in analyzing cancer drug responses, as they reveal systematic variation in cell line and drug class responses.
2013·294citations·M. Fallahi-Sichani et al.·Nature chemical biology
Nature chemical biology
Mitosis-targeted anti-cancer therapies: where they stand
Antimitotic therapies show promise in targeting cancer cells during mitosis, but overcoming the unpredictable human body's response remains a challenge for clinical success.
2012·277citations·K-S Chan et al.·Cell Death & Disease
Cell Death & Disease
Discovery of novel PI3-kinase δ specific inhibitors for the treatment of rheumatoid arthritis: taming CYP3A4 time-dependent inhibition.
Novel, potent, and selective PI3K inhibitors show potential for treating rheumatoid arthritis by targeting B cell activity and CYP3A4 time-dependent inhibition.
2012·62citations·B. Safina et al.·Journal of medicinal chemistry
Journal of medicinal chemistry
Potent and selective aminopyrimidine-based B-Raf inhibitors with favorable physicochemical and pharmacokinetic properties.
New aminopyrimidine-based B-Raf inhibitors with improved solubility and pharmacokinetic profiles show strong efficacy in a B-Raf(V600E) mutant mouse xenograft model.
2012·43citations·S. Mathieu et al.·Journal of medicinal chemistry
Journal of medicinal chemistry
Citations
Design, Synthesis and Anticancer Activity of New Polycyclic: Imidazole, Thiazine, Oxathiine, Pyrrolo-Quinoxaline and Thienotriazolopyrimidine Derivatives
New polycyclic aromatic compounds show significant anticancer activity against various human cancer cell lines.
2021·22citations·A. Abu‐Hashem et al.·Molecules
Molecules
H+-dependent inorganic phosphate transporter in breast cancer cells: Possible functions in the tumor microenvironment.
An H+-dependent inorganic phosphate transporter in breast cancer cells may provide an alternative pathway for phosphate uptake in the tumor microenvironment, potentially regulating energetically expensive tumor processes.
2019·21citations·M. A. Lacerda-Abreu et al.·Biochimica et biophysica acta. Molecular basis of disease
Biochimica et biophysica acta. Molecular basis of disease
Characterization of inorganic phosphate transport in the triple-negative breast cancer cell line, MDA-MB-231
Inorganic phosphate transport in breast cancer cells is modulated by sodium and intracellular sodium gradient, suggesting it as a potential target for therapy against tumor progression.
2018·22citations·T. Russo-Abrahão et al.·PLoS ONE
PLoS ONE
Synthesis and evaluation of antitumor activity of new 4-substituted thieno[3,2-d]pyrimidine and thienotriazolopyrimidine derivatives
Most newly synthesized compounds show potent anticancer activity comparable to doxorubicin, including human breast adenocarcinoma.
2017·6citations·H. Hafez et al.·Acta Pharmaceutica
Acta Pharmaceutica