Many hypotheses have been proposed for the pathogenesis of schizophrenia. The most common hypotheses of schizophrenia are dopaminergic, serotoninergic, glutamatergic. There are also assumptions about involvement of other neurochemical systems, in particular GABAergic, in the pathogenesis of schizophrenia. The available data on the damage of GABAergic interneurons, taking into account the results of postmortem, neuroimaging, molecule-genetic, electrophysiological studies in humans and fundamental studies in animals, are discussed. The author suggests that one of the pathophysiological mechanisms of the pathogenesis of schizophrenia may be a disturbance of myelination of GABAergic interneurons leading to a decrease in the number of intra- and interhemispheric coherent connections, and eventually to the development of symptoms of the disease.

Disturbance of myelination of GABAergic interneurons may contribute to the pathogenesis of schizophrenia by reducing intra- and interhemispheric coherent connections.

Neuromorphological Aspects of the GABAergic Hypothesis of the Pathogenesis of Schizophrenia

Key Takeaway: Disturbance of myelination of GABAergic interneurons may contribute to the pathogenesis of schizophrenia by reducing intra- and interhemispheric coherent connections.