The association between periodontitis and interleukin-6 genetic polymorphism -174 G/C: A meta-analysis.
Bo Zhao, Ronghua Li
Dec 1, 2018
Citations
12
Citations
Quality indicators
Journal
Archives of oral biology
Full text
Semantic Scholar
Key Takeaway Key Takeaway: IL6 -174 G/C polymorphism may be negatively associated with the risk of periodontitis, with a more significant reduction in general and overall periodontitis risk in Brazilian people.
Abstract
BACKGROUND To evaluate the association between periodontitis and interleukin-6 (IL6) -174 G/C polymorphism by data synthesis and subgroup analysis. METHODS Eighteen case-control studies from 16 articles with 1616 cases and 1511 controls were included in this meta-analysis by searching the public databases including PubMed, Embase and Web of Science databases by Jun 2018. Data syntheses were performed using Stata 9.0. RESULTS There were inverse associations of IL6 -174 G/C polymorphism with both general periodontitis and overall periodontitis. In CC vs. GG inheritance model, whose effect was the most profound, the genetic polymorphism reduced the risks of general and overall periodontitis by 60% (95% CI = 0.25-0.65, P < 0.01) and 31% (95% CI = 0.38-0.97, P = 0.04) respectively. In addition, the G/C variation was likely to be protective against moderate (allele C vs. allele G: OR = 0.61, 95% CI = 0.43-0.87, P = 0.01; CC + GC vs. GG: OR = 0.57, 95% CI = 0.37-0.89, P = 0.01) and severe periodontitis (allele C vs. allele G: OR = 0.58, 95% CI = 0.41-0.84, P < 0.01; CC vs. GG: OR = 0.33, 95% CI = 0.13-0.82, P = 0.02) exclusively in Brazilian people. No reliable evidence was found regarding chronic periodontitis. CONCLUSION This meta-analysis suggests that IL6 -174 G/C polymorphism may be negatively associated with risk of periodontitis.