Functional Asymmetry of the Cerebral Hemispheres: Its Role in the Pathogenesis of Ectromelia and Melanoma in (CBAxC57BL/6)F1 Mice
V. Abramov, I. Gontova, I. Ignatiev
Jul 16, 2010
Citations
2
Citations
Quality indicators
Journal
Neuroscience and Behavioral Physiology
Full text
Semantic Scholar
Key Takeaway Key Takeaway: Functional asymmetry in the cerebral hemispheres plays a role in the pathogenesis of infectious and oncological diseases in (CBAxC57BL/6)F1 mice.
Abstract
The aim of the present work was to identify the role of functional asymmetry in the cerebral hemispheres in the pathogenesis of infectious and oncological pathology in (CBAxC57BL/6)F1 mice. Mice with lefthemisphere dominance of motor functions (“right-handers”) were found to be more resistant to infection with ectromelia virus and to show slower growth of tumors after subcutaneous injection of B-16 melanoma than animals with right-hemisphere dominance of motor control (“left-handers”). Thus, this report provides the first evidence for the role of functional asymmetry of the nervous system in the pathogenesis of ectromelia and melanoma (B-16) in (CBAxC57BL/6)F1 mice.