R. Adelman, J. Wright
Developmental pharmacology and therapeutics
Systolic blood pressure and heart rate were measured in beagle puppies from 1 week to 6 months of age. A significant increase in blood pressure and decrease in heart rate occurred with growth. These changes are qualitatively similar to those observed in young infants and children. The beagle puppy may be a useful animal model for the study of normal and abnormal maturational changes in blood pressure and heart rate and for the evaluation of pharmacologic agents currently used in the treatment of cardiovascular disease in the growing and developing infant.